The effect of fluvastatin on chronic CSE-induced inflammatory cell infiltrate. Fluvastatin (p.o., b.i.d.) reduced CSE-induced neutrophil (A) and macrophage (B) infiltrate, but did not reduce the number of lymphocytes (C). Data from CSE mice are represented by black bars, data from sham controls represented by white bars, data from the CSE with compound treatment in gray, diagonal-striped bars. Data plotted as the mean ± sem with an n = 8-10 for each group. Significance (* = p < 0.05, ** = p < 0.01, *** = p < 0.001) was determined versus smoke vehicle control group.