Figure 7

Administration of anti-RSV moAb reduces the length and peak of RSV RNA detection in the blood and is associated with improved airway obstruction. Fig. 7A. Blood RSV RNA loads were measured by real-time PCR on day 4, one day after treatment with anti-RSV moAb, and then on days 5, 7, 10, 14 and 21 in mice infected with RSV (white circle), mice infected with RSV and treated 72 h later with anti-RSV moAb (black triangle) and controls (not represented). Data shown are the result of two separate experiments each with 4 mice per time-point per group. Comparisons were made by Mann-Whitney Rank Test *p < 0.05. Fig. 7B. Non-infected controls (grey circle), RSV-infected mice + treated 72 h later with anti-RSV moAb (black circle) and RSV infected-non treated mice (black triangle) were evaluated for AO, by measuring Penh via whole-body plethysmography. Penh was significantly lower in mice inoculated with RSV and treated with anti-RSV moAb at days 5 and 6 post-inoculation compared with RSV infected non-treated mice. Comparisons made by One way Analysis of Variance * p < 0.05. Red arrow indicates the time of therapeutic intervention with anti-RSV moAb at 72 h post RSV inoculation.