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Table 4 Main anthropometric, clinical, functional, and radiological variables in patients with COPD, stratified according to disease severity (GOLD) and the presence or absence of chronic bronchitis (mean ± SD or proportion).

From: Characterisation of COPD heterogeneity in the ECLIPSE cohort

  GOLD II GOLD III GOLD IV Comparing
  Yes No p-value Yes No p-value Yes No p-value GOLD Stage within Yes GOLD Stage within No
Clinical data
N 294 660   337 574   118 178    
Age (years) 62.6 (7.5) 63.8 (7.0) 0.018 63.2 (7.4) 64.0 (6.7) 0.183 62.0 (7.6) 62.7 (6.6) 0.698 0.335 0.043
Male (%) 193 (66%) 381 (58%) 0.021 258 (77%) 360 (63%) < 0.001 96 (81%) 123 (69%) 0.019 < 0.001 0.014
Pack-years 49.0 (29.3) 47.7 (28.1) 0.423 50.3 (27.3) 48.5 (24.6) 0.450 50.1 (28.9) 48.7 (26.1) 0.870 0.578 0.172
Current smokers (%) 153 (52%) 207 (31%) < 0.001 154 (46%) 187 (33%) < 0.001 44 (37%) 38 (21%) 0.003 0.021 0.015
BMI (kg/m2) 26.7 (5.4) 27.7 (5.8) 0.007 26.0 (5.5) 26.3 (5.6) 0.415 24.3 (5.4) 25.4 (5.9) 0.140 < 0.001 < 0.001
FFMI (kg/m2) 17.4 (2.7) 17.6 (3.0) 0.339 17.0 (2.5) 17.0 (2.9) 0.387 16.4 (2.6) 16.4 (2.6) 0.986 0.008 < 0.001
mMRC Score 1.5 (1.0) 1.3 (1.0) 0.002 1.8 (1.0) 1.8 (1.1) 0.861 2.4 (1.0) 2.3 (1.0) 0.739 < 0.001 < 0.001
SGRQ-C total score 50.3 (18.8) 38.9 (20.5) < 0.001 58.8 (17.6) 51.2 (18.2) < 0.001 65.0 (16.5) 59.4 (15.2) 0.010 < 0.001 < 0.001
Number of exacerbationsa 0.7 (1.1) 0.6 (1.0) 0.132 1.0 (1.2) 1.0 (1.4) 0.253 1.2 (1.6) 1.2 (1.3) 0.436 < 0.001 < 0.001
Physiology
FEV1 % Predicted 62.3 (8.8) 63.5 (8.2) 0.030 40.3 (5.7) 40.3 (5.9) 0.957 25.1 (3.4) 24.5 (3.8) 0.322 < 0.001 < 0.001
FEV1/FVC (%) 52.3 (9.0) 53.0 (8.7) 0.358 41.0 (9.4) 40.1 (8.6) 0.199 32.2 (8.6) 31.9 (6.8) 0.985 < 0.001 < 0.001
FEV1 reversibility (%) 10.8 (12.4) 11.4 (12.8) 0.222 11.2 (15.1) 10.9 (14.3) 0.826 8.2 (15.3) 7.8 (12.9) 0.866 0.070 0.001
6MWD (metres) 397 (118) 409 (109) 0.059 352 (113) 358 (121) 0.289 306 (125) 278 (115) 0.106 < 0.001 < 0.001
BODE Index 1.8 (1.4) 1.5 (1.3) < 0.001 4.0 (1.6) 3.9 (1.7) 0.430 5.7 (1.7) 5.8 (1.5) 0.730 < 0.001 < 0.001
Imaging
Emphysema (%) 12.3 (10.3) 12.0 (9.2) 0.854 19.1 (11.7) 20.5 (11.5) 0.082 28.3 (13.4) 28.1 (12.1) 0.822 < 0.001 < 0.001
Bronchiectasis (%) 3 (1%) 10 (2%) 0.644 22 (8%) 19 (4%) 0.006 7 (7%) 13 (8%) 0.797 0.001 < 0.001
  1. aIn the year prior to study entry.