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Table 3 Main anthropometric, clinical, functional, and radiological variables in patients with COPD, stratified according to the BODE index and gender (mean ± SD or proportion).

From: Characterisation of COPD heterogeneity in the ECLIPSE cohort

  BODE 0 1 2 BODE 3 4 BODE 5 6 BODE 7 8 9 10 Differences within females Differences within males
  Females Males p value Females Males p value Females Males p value Females Males p value Females Males
BODE Index 1.1 ± 0.8 1.3 ± 0.8 0.014 3.5 ± 0.5 3.4 ± 0.5 0.088 5.4 ± 0.5 5.4 ± 0.5 0.874 7.5 ± 0.8 7.5 ± 0.7 0.658 < 0.001 < 0.001
  Clinical data
Age (years) 62.3 ± 7.0 63.5 ± 7.3 0.008 62.8 ± 6.8 63.6 ± 7.2 0.132 62.3 ± 7.0 64.9 ± 6.6 0.001 63.9 ± 7.1 63.9 ± 7.0 0.949 0.362 0.090
Pack years (n) 39.7 ± 20.5 51.0 ± 29.2 < 0.001 43.3 ± 22.2 50.6 ± 27.7 0.001 43.6 ± 22.9 55.7 ± 28.0 < 0.001 41.9 ± 17.8 57.8 ± 31.8 < 0.001 0.186 0.002
BMI (Kg/m2) 26.4 ± 5.0 27.3 ± 4.5 0.001 26.1 ± 6.1 26.6 ± 5.5 0.162 26.4 ± 8.1 26.3 ± 6.1 0.596 23.8 ± 7.0 25.9 ± 6.0 0.017 0.006 < 0.001
FFMI (Kg/m2) 15.9 ± 2.7 18.4 ± 2.3 < 0.001 15.5 ± 2.3 17.9 ± 2.7 < 0.001 15.8 ± 3.0 17.6 ± 2.9 < 0.001 14.9 ± 3.0 17.1 ± 2.4 < 0.001 0.001 < 0.001
MMRC score 0.9 ± 0.7 0.9 ± 0.7 0.893 1.8 ± 0.7 1.8 ± 0.8 0.443 2.6 ± 0.9 2.5 ± 0.8 0.619 3.1 ± 0.8 3.3 ± 0.6 0.051 < 0.001 < 0.001
SGRQ total score 38.0 ± 17.1 38.0 ± 18.7 0.961 54.1 ± 15.5 53.0 ± 16.1 0.541 63.1 ± 16.1 62.6 ± 14.6 0.809 70.2 ± 12.9 72.5 ± 13.2 0.352 < 0.001 < 0.001
Exacerbations a(n) 0.6 ± 1.0 0.5 ± 0.9 0.006 1.1 ± 1.4 0.9 ± 1.3 0.152 1.5 ± 1.4 1.2 ± 1.5 0.006 1.6 ± 1.7 1.1 ± 1.2 0.276 < 0.001 < 0.001
  Physiology
Post-BD FEV1 (% ref). 62.1 ± 9.8 58.8 ± 11.7 < 0.001 46.6 ± 12.2 42.8 ± 12.1 0.001 37.9 ± 10.8 34.4 ± 9.4 0.003 32.6 ± 8.8 29.1 ± 8.5 0.022 < 0.001 < 0.001
Post-BD FEV/FVC (%) 51.9 ± 9.1 49.7 ± 10.0 0.003 44.5 ± 10.4 41.9 ± 11.1 0.004 40.0 ± 10.6 36.9 ± 9.9 0.009 39.7 ± 9.9 35.0 ± 8.6 0.003 < 0.001 < 0.001
FEV1 reversibility (%) 10.5 ± 12.5 11.3 ± 13.6 0.319 9.7 ± 14.8 12.2 ± 15.2 0.020 10.5 ± 14.4 10.6 ± 12.3 0.687 7.8 ± 12.8 8.3 ± 14.0 0.787 0.300 0.072
6MWD (metres) 432 ± 93 447 ± 94 0.013 349 ± 91 379 ± 95 < 0.001 269 ± 88 289 ± 84 0.015 164 ± 74 185 ± 67 0.084 < 0.001 < 0.001
  Imaging
LAA 11.3 ± 9.9 13.8 ± 9.7 < 0.001 17.7 ± 11.1 19.0 ± 11.5 0.244 22.6 ± 13.2 23.6 ± 13.1 0.616 25.5 ± 13.6 28.9 ± 12.6 0.171 < 0.001 < 0.001
  1. aIn the year prior to study entry.