Skip to main content

Table 3 Main anthropometric, clinical, functional, and radiological variables in patients with COPD, stratified according to the BODE index and gender (mean ± SD or proportion).

From: Characterisation of COPD heterogeneity in the ECLIPSE cohort

 

BODE 0 1 2

BODE 3 4

BODE 5 6

BODE 7 8 9 10

Differences within females

Differences within males

 

Females

Males

p value

Females

Males

p value

Females

Males

p value

Females

Males

p value

Females

Males

BODE Index

1.1 ± 0.8

1.3 ± 0.8

0.014

3.5 ± 0.5

3.4 ± 0.5

0.088

5.4 ± 0.5

5.4 ± 0.5

0.874

7.5 ± 0.8

7.5 ± 0.7

0.658

< 0.001

< 0.001

 

Clinical data

Age (years)

62.3 ± 7.0

63.5 ± 7.3

0.008

62.8 ± 6.8

63.6 ± 7.2

0.132

62.3 ± 7.0

64.9 ± 6.6

0.001

63.9 ± 7.1

63.9 ± 7.0

0.949

0.362

0.090

Pack years (n)

39.7 ± 20.5

51.0 ± 29.2

< 0.001

43.3 ± 22.2

50.6 ± 27.7

0.001

43.6 ± 22.9

55.7 ± 28.0

< 0.001

41.9 ± 17.8

57.8 ± 31.8

< 0.001

0.186

0.002

BMI (Kg/m2)

26.4 ± 5.0

27.3 ± 4.5

0.001

26.1 ± 6.1

26.6 ± 5.5

0.162

26.4 ± 8.1

26.3 ± 6.1

0.596

23.8 ± 7.0

25.9 ± 6.0

0.017

0.006

< 0.001

FFMI (Kg/m2)

15.9 ± 2.7

18.4 ± 2.3

< 0.001

15.5 ± 2.3

17.9 ± 2.7

< 0.001

15.8 ± 3.0

17.6 ± 2.9

< 0.001

14.9 ± 3.0

17.1 ± 2.4

< 0.001

0.001

< 0.001

MMRC score

0.9 ± 0.7

0.9 ± 0.7

0.893

1.8 ± 0.7

1.8 ± 0.8

0.443

2.6 ± 0.9

2.5 ± 0.8

0.619

3.1 ± 0.8

3.3 ± 0.6

0.051

< 0.001

< 0.001

SGRQ total score

38.0 ± 17.1

38.0 ± 18.7

0.961

54.1 ± 15.5

53.0 ± 16.1

0.541

63.1 ± 16.1

62.6 ± 14.6

0.809

70.2 ± 12.9

72.5 ± 13.2

0.352

< 0.001

< 0.001

Exacerbations a(n)

0.6 ± 1.0

0.5 ± 0.9

0.006

1.1 ± 1.4

0.9 ± 1.3

0.152

1.5 ± 1.4

1.2 ± 1.5

0.006

1.6 ± 1.7

1.1 ± 1.2

0.276

< 0.001

< 0.001

 

Physiology

Post-BD FEV1 (% ref).

62.1 ± 9.8

58.8 ± 11.7

< 0.001

46.6 ± 12.2

42.8 ± 12.1

0.001

37.9 ± 10.8

34.4 ± 9.4

0.003

32.6 ± 8.8

29.1 ± 8.5

0.022

< 0.001

< 0.001

Post-BD FEV/FVC (%)

51.9 ± 9.1

49.7 ± 10.0

0.003

44.5 ± 10.4

41.9 ± 11.1

0.004

40.0 ± 10.6

36.9 ± 9.9

0.009

39.7 ± 9.9

35.0 ± 8.6

0.003

< 0.001

< 0.001

FEV1 reversibility (%)

10.5 ± 12.5

11.3 ± 13.6

0.319

9.7 ± 14.8

12.2 ± 15.2

0.020

10.5 ± 14.4

10.6 ± 12.3

0.687

7.8 ± 12.8

8.3 ± 14.0

0.787

0.300

0.072

6MWD (metres)

432 ± 93

447 ± 94

0.013

349 ± 91

379 ± 95

< 0.001

269 ± 88

289 ± 84

0.015

164 ± 74

185 ± 67

0.084

< 0.001

< 0.001

 

Imaging

LAA

11.3 ± 9.9

13.8 ± 9.7

< 0.001

17.7 ± 11.1

19.0 ± 11.5

0.244

22.6 ± 13.2

23.6 ± 13.1

0.616

25.5 ± 13.6

28.9 ± 12.6

0.171

< 0.001

< 0.001

  1. aIn the year prior to study entry.