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Table 1 Summary of Change in Hemodynamic Outcomes with Intervention Compared to Placebo/Control

From: Pharmacotherapy in pulmonary arterial hypertension: a systematic review and meta-analysis

Drug Class mPAP mRAP PVR Cardiac Index
Prostanoids -4.2 (-6.2, -2.1) -1.6 (-2.3, -0.9) -291 (-401, -182) 0.32 (0.12, 0.52)
Endothelin receptor antagonists -4.9 (-6.6, -3.2) -1.4 (-2.9, 0.2) -245 (-316, -174) 0.30 (0.09, 0.51)
Phosphodiesterase type 5 inhibitors -4.2 (-5.7, -2.7) -1.8 (-2.8, -0.8) -192 (259, 126) 0.39 (0.15, 0.63)*
  1. Data are reported as mean placebo/control-corrected change (95% confidence interval)
  2. mPAP, mean pulmonary artery pressure; mRAP, mean right atrial pressure; PVR, pulmonary vascular resistance
  3. * reported only in Galie et al, 2005 [29]