Skip to main content
Figure 6 | Respiratory Research

Figure 6

From: Hypertonic saline increases lung epithelial lining fluid glutathione and thiocyanate: two protective CFTR-dependent thiols against oxidative injury

Figure 6

Illustration depicting the potential role of hypertonic saline mediated changes in GSH and SCN levels and protection against HOCl mediated lung injury. The normal airways (A) have the ability to export large amounts of both GSH and SCN into the ELF through CFTR and an unknown transporter to detoxify the relatively low amount of HOCl produced from neutrophil derived MPO. Whereas in the CF airways (B) there is a large excess of MPO producing higher amounts of HOCl. Consequently the deficiency in CFTR leads to lower levels of both GSH and SCN in the ELF which is not fully sufficient at protecting against lung injury.

Back to article page