Fiber knob binding site alignment. Alignment of the amino acid sequences on the exposed regions of the fiber loops FG, HI, and IJ that are involved in binding to CD46. Black arrow demarcates the ΔK250-E251 deletion. All sequences were aligned using the ClustalX  alignment method. The following HAdV genomes (GenBank accession numbers) were used: HAdV-14p (AY803294), HAdV-11p (AY163756), HAdV-3 (NC_011203), HAdV-7 (AC_000018), and HAdV-21 (AY601633).