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Table 2 Analysis of cytokines in nasal lavages

From: Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold

  first visit day 1 second visit day 3/4 second visit day 3/4  
  all Iota-Carrageenan Placebo p-value
FGF-2 5.9 (5.9) 2.5 (2.8) 7.5 (5.6) 0.04
Fractalkine 87.0 (74.5) 46.4 (32.4) 79.7 (39.3) 0.023
GRO 252 (233) 156 (112) 339 (417) n.s.
G-CSF 45.5 (89.1) 10.9 (17.9) 78.5 (186) n.s.
IL-8 18.7 (30.6) 14.4 (10.8) 21.0 (22.4) n.s.
IL-1α 35.3 (30.0) 28.8 (14.4) 43.1 (28.9) n.s.
IP-10 1790 (3177) 970 (1769) 3016 (4033) n.s.
IL-10 1.6 (4.22) 0 (0) 5.5 (13.6) 0.049
IL-1ra 164 (129) 174 (320) 131 (85) n.s.
IFN-α2 11.6 (8.0) 8.7 (4.1) 11.5 (5.6) n.s.
IL-12(p40) 10.6 (14.0) 9.1 (9.7) 8.0 (9.8) n.s.
  1. Comparison of cytokine levels on day 1 and day 3/4. Shown are mean levels in pg/ml ± standard deviation. Lower quantification limit was 3.2 pg/ml, values below were set to '0'. P-values: comparison verum versus placebo by Mann-Whitney U-test.
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