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Table 2 Sputum before and after amp Provocation

From: Can AMP induce sputum eosinophils, even in subjects with complete asthma remission?

  Complete remission Current asthma
  (n = 7) Total group
(n = 23)
Negative
PC 20 AMP
(n = 12)
Positive
PC 20 AMP
(n = 11)
Total cells (×10 6 /ml)
Baseline 0.6 (0.1 - 2.9) 0.3 (0.1 - 2.3) 0.4 (0.1 - 2.3) 0.3 (0.2 - 2.1)
After AMP 0.2 (0.1 - 1.4) θ 0.3 (0.1 - 3.0) 0.4 (0.2 - 3.0) 0.3 (0.1 - 0.8)
Change -0.5 (-1.5 - 0.0) 0.0 (-1.7 - 1.5) 0.1 (-1.1 - 1.5) 0.0 (-1.7 - 0.2)
Squamous cells (%)
Baseline 23.8 (5.3 - 67.0) 21.3 (0.8 - 70.3) 19.2 (0.8 - 70.3) 21.3 (4.7 - 43.3)
After AMP 41.5 (9.0 - 49.0) 17.5 (0.5 - 64.5) 19.9 (0.5 - 64.5) 17.5 (1.7 - 24.5)
Change 14.0 (-26.2 - 22.2) -2.0 (-25.8 - 27.0) -1.1 (-16.5 - 27.0) -2.0 (-25.8 - 10.6)
Neutrophils (%)
At baseline 62.2 (18.9 - 77.6) 55.2 (19.8 - 94.5) 56.8 (20.7 - 94.5) 55.2 (19.8 - 93.6)
After AMP 48.1 (15.0 - 90.4) 59.0 (22.3 - 96.8) 71.3 (25.7 - 96.8) 52.7 (22.3 - 71.0)
Change -3.9 (-37.9 - 58.1) -3.2 (-35.1 - 68.0) -0.4 (-29.5 - 68.0) -5.1 (-35.1 - 25.4)
Macrophages (%)
At baseline 35.8 (19.9 - 77.7) 32.7 (5.3 - 76.4) 40.0 (5.3 - 76.4) 32.7 (5.6 - 76.2)
After AMP 49.1 (8.9 - 84.2) 29.2 (3.0 - 72.5) 23.1 (3.0 - 72.5) 39.1 (12.6 - 61.2)
Change 11.2 (-56.7 - 41.3) 1.2 (-65.1 - 28.6) 0.0 (-65.1 - 28.6) 1.2 (-37.1 - 20.6)
Eosinophils (%)
At baseline 0.2 (0.0 - 4.6) 0.5 (0.0 - 25.7) 0.2 (0.0 - 1.8)‡‡ 1.9 (0.0 - 25.7)
After AMP 0.2 (0.0- 2.6)*, ‡‡‡ 2.6 (0.0 - 32.0)θ θ θ 1.3 (0.0 - 6.3)‡‡‡, θ 5.9 (2.5 - 32.0)θ θ
Change -0.2 (-2.3 - 0.2)**, ‡‡, §§ 1.4 (-2.3 - 13.7) 0.7 (-0.5 - 6.1) 2.7 (-2.3 - 13.7)
Lymphocytes (%)
At baseline 2.2 (1.4 - 7.3) 1.9 (0.0 - 6.9) 2.0 (0.2 - 6.9) 1.9 (0.0 - 5.9)
After AMP 0.3 (0.0 - 2.5)*, ‡‡, θ, § 1.3 (0.0 - 6.1) 0.8 (0.0 - 6.1) 1.7 (0.7 - 4.8)
Change -1.8 (-7.0 - 0.7) -0.2 (-4.9 - 4.8) -0.4 (-4.2 - 3.8) 0.1 (-4.9 - 4.8)
  1. Squamous cells were not included in the number of total cells and in the percentages of all other cell types.
  2. Values are medians (ranges).
  3. * p ≤ 0.05, ** p ≤ 0.01 versus current asthma total group.
  4. p ≤ 0.05, ‡‡ p ≤ 0.01, ‡‡‡ p ≤ 0.001 versus current asthma PC20 AMP positive.
  5. § p ≤ 0.05, §§ p ≤ 0.01 versus current asthma PC20 AMP negative.
  6. θ p ≤ 0.05, θ θ p ≤ 0.01, θ θ θ p = 0.001 versus at baseline.