From: Can AMP induce sputum eosinophils, even in subjects with complete asthma remission?
Complete remission | Current asthma | |||
---|---|---|---|---|
(n = 7) | Total group (n = 23) | Negative PC 20 AMP (n = 12) | Positive PC 20 AMP (n = 11) | |
Total cells (×10 6 /ml) | ||||
Baseline | 0.6 (0.1 - 2.9) | 0.3 (0.1 - 2.3) | 0.4 (0.1 - 2.3) | 0.3 (0.2 - 2.1) |
After AMP | 0.2 (0.1 - 1.4) θ | 0.3 (0.1 - 3.0) | 0.4 (0.2 - 3.0) | 0.3 (0.1 - 0.8) |
Change | -0.5 (-1.5 - 0.0) | 0.0 (-1.7 - 1.5) | 0.1 (-1.1 - 1.5) | 0.0 (-1.7 - 0.2) |
Squamous cells (%) | ||||
Baseline | 23.8 (5.3 - 67.0) | 21.3 (0.8 - 70.3) | 19.2 (0.8 - 70.3) | 21.3 (4.7 - 43.3) |
After AMP | 41.5 (9.0 - 49.0) | 17.5 (0.5 - 64.5) | 19.9 (0.5 - 64.5) | 17.5 (1.7 - 24.5) |
Change | 14.0 (-26.2 - 22.2) | -2.0 (-25.8 - 27.0) | -1.1 (-16.5 - 27.0) | -2.0 (-25.8 - 10.6) |
Neutrophils (%) | ||||
At baseline | 62.2 (18.9 - 77.6) | 55.2 (19.8 - 94.5) | 56.8 (20.7 - 94.5) | 55.2 (19.8 - 93.6) |
After AMP | 48.1 (15.0 - 90.4) | 59.0 (22.3 - 96.8) | 71.3 (25.7 - 96.8) | 52.7 (22.3 - 71.0) |
Change | -3.9 (-37.9 - 58.1) | -3.2 (-35.1 - 68.0) | -0.4 (-29.5 - 68.0) | -5.1 (-35.1 - 25.4) |
Macrophages (%) | ||||
At baseline | 35.8 (19.9 - 77.7) | 32.7 (5.3 - 76.4) | 40.0 (5.3 - 76.4) | 32.7 (5.6 - 76.2) |
After AMP | 49.1 (8.9 - 84.2) | 29.2 (3.0 - 72.5) | 23.1 (3.0 - 72.5) | 39.1 (12.6 - 61.2) |
Change | 11.2 (-56.7 - 41.3) | 1.2 (-65.1 - 28.6) | 0.0 (-65.1 - 28.6) | 1.2 (-37.1 - 20.6) |
Eosinophils (%) | ||||
At baseline | 0.2 (0.0 - 4.6) | 0.5 (0.0 - 25.7) | 0.2 (0.0 - 1.8)‡‡ | 1.9 (0.0 - 25.7) |
After AMP | 0.2 (0.0- 2.6)*, ‡‡‡ | 2.6 (0.0 - 32.0)θ θ θ | 1.3 (0.0 - 6.3)‡‡‡, θ | 5.9 (2.5 - 32.0)θ θ |
Change | -0.2 (-2.3 - 0.2)**, ‡‡, §§ | 1.4 (-2.3 - 13.7) | 0.7 (-0.5 - 6.1)‡ | 2.7 (-2.3 - 13.7) |
Lymphocytes (%) | ||||
At baseline | 2.2 (1.4 - 7.3) | 1.9 (0.0 - 6.9) | 2.0 (0.2 - 6.9) | 1.9 (0.0 - 5.9) |
After AMP | 0.3 (0.0 - 2.5)*, ‡‡, θ, § | 1.3 (0.0 - 6.1) | 0.8 (0.0 - 6.1) | 1.7 (0.7 - 4.8) |
Change | -1.8 (-7.0 - 0.7) | -0.2 (-4.9 - 4.8) | -0.4 (-4.2 - 3.8) | 0.1 (-4.9 - 4.8) |