Asthma and gender impact accumulation of T cell subtypes

Respiratory Research

Table 2 Impact of regular inhaled corticosteroid use on T cell subset accumulation.

Culture stimulus	T cell subset	Asthma group		Accumulation, % of day 0 numbers *			p-value ^†
		Gender	Steroid ^•	Geo. Mean	Geo. Mean ± S.D.	n	Gender	Steroid	Interaction
IL-2	IL-13⁺	Female	No	622	326 - 1184	6	0.0016	0.16	0.22
			Yes	662	342 - 1280	5
		Male	No	116	73 - 184	2
			Yes	285	155 - 525	5
	IFN-γ⁺	Female	No	677	229 - 1994	6	0.41	0.28	0.40
			Yes	170	69 - 420	4
		Male	No	206	101 - 423	3
			Yes	173	21 - 1415	6
CD3+CD28	IL-13⁺	Female	No	5427	1281-22,996	3	0.0016	0.044	0.33
+ IL-2			Yes	1352	571 - 3,201	6
		Male	No	656	393 - 1,094	3
			Yes	388	204 - 738	6
	IFN-γ⁺	Female	No	3730	886 - 15,702	3	0.073	0.023	0.98
			Yes	691	241 - 1,982	6
		Male	No	1035	396 - 2,707	3
			Yes	186	36 - 962	7

* Two-way General Linear Model analysis was performed to adjust for the impact of regular steroid use and gender on accumulation of T cell subsets from asthmatic subjects. Geo. Mean = geometric mean for the numbers of IL-13+ or IFN-γ+ T cells relative to the respective day 0 numbers after culture with the indicated culture stimulus. S.D. = standard deviation.
^† The significance of differences in geometric mean between males and females (gender) and between asthma subjects that use or don't regularly use inhaled steroids (steroid), and the significance of interaction between gender and steroid effects.
^• Indicates whether asthma subjects regularly use inhaled corticosteroids for asthma control. Note that all asthma subjects refrained from using asthma control medications 12-h before blood draw. No subjects regularly used oral corticosteroids for asthma control.

ISSN: 1465-993X