Asthma and gender impact accumulation of T cell subtypes

Respiratory Research

Table 1 Proportions of IL-13⁺ and IFN-γ⁺ T cells after culture.

Stimulus *	Subset	Subjects	Median ^†	IQR ^†	n	p ^‡
CD3+CD28	IL-13⁺	Control	0.8%	0.6 - 4.3	17	0.67
+IL-2		Asthma	1.8%	0.5 - 4.2	18
	IFN-γ⁺	Control	2.9%	0.6 - 7.8	11	0.035
		Asthma	7.4%	5.1 - 20.2	19
IL-2	IL-13⁺	Control	1.0%	0.7 - 3.2	24	0.0004
		Asthma	4.5%	2.5 - 5.3	18
	IFN-γ⁺	Control	4.1%	2.4 - 10.3	19	0.0076
		Asthma	10.7%	7.2 - 24.2	19

* After 5-day (CD3+CD28+IL-2) or 6-day (IL-2) culture of PBL (anti-IL-12 monoclonal antibody included in all cultures), proportions of cytokine-producing T cells were determined by flow cytometry.
^† Median and 25%-75% interquartile range (IQR) of the proportion of IL-13+ or IFN-γ⁺ T cell subsets.
^‡p-value for the significance of difference between control and asthmatic subjects (two-tailed Mann-Whitney test).

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