Skip to main content
Figure 5 | Respiratory Research

Figure 5

From: Host lung gene expression patterns predict infectious etiology in a mouse model of pneumonia

Figure 5

Diagnostic accuracy of computerized gene expression interrogation. Mice were exposed to one of four potential infectious conditions, then gene expression profiling was performed at designated time points after the challenge. (A) Diagnostic accuracy of algorithmic predictions of whether or not different mice were infected with bacteria, based on the time after infection and the number of transcripts used in the prediction model. (B-D) Rules derived from initial 18 h experiments were used to predict the infectious conditions of different mice 18 h after challenge in a separate validation set, based on number of transcripts in the algorithm. (B) Prediction accuracy for discriminating bacteria vs. non-bacteria. (C) Prediction accuracy for discriminating S. pneumoniae infection from P. aeruginosa infection. (D) Prediction accuracy for discriminating A. fumigatus from sham infection.

Back to article page