Figure 1
From: Host lung gene expression patterns predict infectious etiology in a mouse model of pneumonia
Survival following infectious challenges. (A) Using an experimental model of inhalational pneumonia in BALB/c mice, P. aeruginosa and S. pneumoniae both induced consistent mortality >80%, while mice challenged with A. fumigatus or PBS (sham) had 100% survival. (B) Mice treated with cyclophosphamide and cortisol prior to infection also consistently succumbed to A. fumigatus challenge, substantiating the effective delivery of pathogens to the mice (N = 10 mice/group, *p = 0.0007 vs. A. fumigatus, **p = 0.0001 vs. A. fumigatus, †p < 0.0001 vs. A. fumigatus).