Figure 5
From: Different regulation of cigarette smoke induced inflammation in upper versus lower airways
Gene expression analysis in lung. Pulmonary levels of GCP-2, KC, MCP-1, MIP-3α and IL-17, but not FoxP3 were significantly increased after 2-wk CS exposure (Fig. 5A). After 4-wk CS exposure, all markers of neutrophilic and monocyte/macrophage chemoattraction are significantly increased, as well as FoxP3 and TGF-β1 (Fig. 5B). Chronic CS exposure caused an increase in levels of GCP-2, KC, MCP-1 and FoxP3 levels (MIP-3α p = 0.05) (Fig. 5C). (n = 8 mice/group, *p < 0.05, **p < 0.01, ***p < 0.001).