Figure 1From: Collagen V-induced nasal tolerance downregulates pulmonary collagen mRNA gene and TGF-beta expression in experimental systemic sclerosisTransversal sections of lungs of immunized rabbits, and lungs after nasal tolerance induction with collagen V, stained by Masson trichromic (A-D) and Picrosirius (E-H). In the immunized animals, thickening of the extracellular matrix is observed, with radial and periaxial distribution (A, B, E, F). After the induction of nasal tolerance with collagen V, there was a decrease in collagen deposition (G, H). TB = terminal bronchiole; V = vessel; Groups: IM = immunized; IM-TOL = immunized and tolerated; Magnification: 200×.Back to article page