Asthma and genes encoding components of the vitamin D pathway

Bossé, Yohan; Lemire, Mathieu; Poon, Audrey H; Daley, Denise; He, Jian-Qing; Sandford, Andrew; White, John H; James, Alan L; Musk, William Arthur; Palmer, Lyle J; Raby, Benjamin A; Weiss, Scott T; Kozyrskyj, Anita L; Becker, Allan; Hudson, Thomas J; Laprise, Catherine

doi:10.1186/1465-9921-10-98

Respiratory Research

Table 2 Single SNP association results for asthma and atopy in the Saguenay^_Lac-Saint-Jean study.

From: Asthma and genes encoding components of the vitamin D pathway

		Asthma					Atopy
Gene	SNP	Allele	Allele frequency	# of families*	Z	P value	Allele frequency	# of families*	Z	P value
IL10	rs4844553	C	0.94	39	2.10	0.036	0.94	33	0.15	0.881
		T	0.06	39	-2.10	0.036	0.06	33	-0.15	0.881
	rs3024490	A	0.28	105	2.42	0.016	0.28	94	0.80	0.423
		C	0.72	105	-2.42	0.016	0.72	94	-0.80	0.423
	rs1800872	A	0.28	105	2.42	0.016	0.28	94	0.80	0.423
		C	0.72	105	-2.42	0.016	0.72	94	-0.80	0.423
	rs1800871	C	0.71	95	-2.52	0.012	0.71	84	-1.22	0.221
		T	0.29	95	2.52	0.012	0.29	84	1.22	0.221
	rs1800896	C	0.46	117	-2.47	0.014	0.46	101	-1.49	0.137
		T	0.54	117	2.47	0.014	0.54	101	1.49	0.137
IL1RL1	rs950880	A	0.39	126	1.73	0.084	0.39	105	1.64	0.100
		C	0.61	126	-1.73	0.084	0.61	105	-1.64	0.100
	rs1420089	C	0.18	72	-2.14	0.033	0.18	60	-0.21	0.832
		T	0.82	72	2.14	0.033	0.82	60	0.21	0.832
	rs1946131	C	0.92	53	-2.44	0.015	0.92	42	-1.96	0.050
		T	0.09	53	2.44	0.015	0.09	42	1.96	0.050
	rs1921622	C	0.54	75	-1.65	0.099	0.54	65	-1.39	0.165
		T	0.46	75	1.65	0.099	0.46	65	1.39	0.165
	rs1861245	A	0.43	101	-2.14	0.032	0.43	74	-1.19	0.235
		G	0.57	101	2.14	0.032	0.57	74	1.19	0.235
CD28	rs6435203	C	0.34	120	-1.97	0.049	0.34	104	-1.17	0.243
		T	0.67	120	1.97	0.049	0.67	104	1.17	0.243
CYP27A1	rs4674338	C	0.60	96	1.85	0.064	0.60	82	1.72	0.085
		T	0.41	96	-1.85	0.064	0.41	82	-1.72	0.085
CD86	rs2715267	A	0.64	102	-1.82	0.069	0.64	91	-2.86	0.004
		C	0.37	102	1.82	0.069	0.37	91	2.86	0.004
	rs2715273	A	0.82	79	1.75	0.081	0.82	65	1.67	0.096
		T	0.18	79	-1.75	0.081	0.18	65	-1.67	0.096
	rs6805035	A	0.88	51	1.74	0.083	0.88	43	1.43	0.154
		C	0.12	51	-1.74	0.083	0.12	43	-1.43	0.154
	rs2332096	A	0.46	117	-1.39	0.164	0.46	108	-1.79	0.074
		C	0.54	117	1.39	0.164	0.54	108	1.79	0.074
CYP2R1	rs11023374	C	0.33	105	2.38	0.017	0.33	88	1.33	0.183
		T	0.67	105	-2.38	0.017	0.67	88	-1.33	0.183
CYP24A1	rs8124792	C	0.95	22	2.18	0.030	0.95	24	1.89	0.058
		T	0.05	22	-2.18	0.030	0.05	24	-1.89	0.058
	rs927650	C	0.55	108	-1.65	0.100	0.55	91	-1.95	0.051
		T	0.45	108	1.65	0.100	0.45	91	1.95	0.051
	rs912505	C	0.29	89	-1.63	0.104	0.29	80	-2.44	0.015
		T	0.71	89	1.63	0.104	0.71	80	2.44	0.015
	rs2248359	C	0.58	112	2.15	0.032	0.58	97	0.56	0.577
		T	0.42	112	-2.15	0.032	0.42	97	-0.56	0.577

*Number of informative families to conduct the test.
P values < 0.05 are shown in bold.

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