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Figure 4 | Respiratory Research

Figure 4

From: Asthma and genes encoding components of the vitamin D pathway

Figure 4

Two-gene model analyses on asthma in the SLSJ study for genes involved in the vitamin D pathway. The plot illustrates the p values for single SNP association and all possible two-SNP combinations. Each line represents a SNP listed at the left of the figure. Each column represents a SNP listed in the same order but from left to right. The white horizontal and vertical lines break up the figure by genes. Gene names are indicated at the right of the figure. P values are illustrated using the following color scheme: grey, p > 0.05; blue, 0.05 > p > 0.01; yellow, 0.01 > p > 0.001; orange, 0.001 > p > 0.0001, red, 0.0001 > p > 0.00001. The squares forming the diagonal (upper-left to lower-right) depict p values for single SNP association based on a Wald test (see materials and methods). Two-gene models for SNPs located in the same gene were not assessed and were not coloured, which created the large white square patterns along the diagonal. Illustrated above the diagonal are p values for the interaction term only, which are the results of Wald tests contrasting the full model (two main effects and the interaction) to the reduced model (two main effects only). Illustrated below the diagonal are p values testing the full model (two main effects and the interaction) against a reduced model that is conditional on single SNPs declared significant when taken individually, if any (see materials and methods). White squares illustrate tests for which the model failed to converge.

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