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Figure 1 | Respiratory Research

Figure 1

From: Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation

Figure 1

The CELLMAX artificial capillary modules and sequence of events that leads from initial apoptosis to proliferation of apoptosis-resistant endothelial cells. The combination of initial apoptosis induced by VEGF receptor blockade and high fluid shear stress generates apoptosis-resistant proliferative endothelial cells. Definition of abbreviations: HPMVEC = human pulmonary microvascular endothelial cell; VEGF = vascular endothelial growth factor; SU5416 = a combined VEGF I and II receptor blocker.

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Respiratory Research

ISSN: 1465-993X

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