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Figure 3 | Respiratory Research

Figure 3

From: PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells

Figure 3

Bradykinin-induced IL-8 release is increased by the Epac activators 8-pCPT-2'- O -Me-cAMP and Sp-8-pCPT-2'- O -Me-cAMPS. hTERT-airway smooth muscle cells were stimulated with the indicated concentrations of 8-pCPT-2'-O-Me-cAMP (A) or with 100 μM of 8-pCPT-2'-O-Me-cAMP, Sp-8-pCPT-2'-O-Me-cAMPS and 8-pCPT-2'-O-Me-cGMP (B) in the absence (Basal) or presence of 10 μM bradykinin for 18 hrs. IL-8 release was measured by ELISA. Results are expressed as mean ± SEM of separate experiments (n = 3-9). **P < 0.01, ***P < 0.001 compared to unstimulated control; # P < 0.05, ## P < 0.01 compared to bradykinin-stimulated control.

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