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Figure 1 | Respiratory Research

Figure 1

From: PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells

Figure 1

cAMP-elevating agent fenoterol augments bradykinin-induced release of IL-8. hTERT-airway smooth muscle cells were stimulated for 18 hrs with the indicated concentrations of bradykinin (A). Cells were incubated for 30 min without (Basal) or with 1 μM fenoterol. Then, cells were stimulated with 10 μM bradykinin for 18 hrs. IL-8 release was assessed by ELISA as described in Materials and Methods. Results are expressed as mean ± SEM of separate experiments (n = 3-10). *P < 0.05, ***P < 0.001 compared to unstimulated control; # P < 0.05 compared to bradykinin-stimulated control.

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