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Table 1 Clinical characteristics of patients at the time of diagnosis of PAH.

From: Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension

BMPR2 mutation Noncarriers
(n = 41)
Carriers
(n = 106)
P value*
Age at Diagnosis, yrs 42.0 (37.4-46.6) 36.1 (33.3-38.8) 0.04
Gender, female/male 3.1/1 2.2/1 0.43
RAP, mm Hg 12.4 (9.8-15.0) 11.1 (8.9-13.3) 0.29
Mean PAP, mm Hg 58.3 (55.0-61.5) 58.6 (55.3-61.8) 0.97
PCWP, mm Hg 10.1 (8.6-11.6) 10.6 (9.1-12.1) 0.77
CI, L/min/m2 1.8 (1.4-2.2) 1.9 (1.7-2.0) 0.92
PVR, mm Hg/L/min 14.0 (12.4-15.5) 18.1 (14.1-22.0) 0.08
SvO2, % 56.4 (52.6-60.3) 58.4 (54.5-62.3) 0.64
  1. * All P values calculated using Mann-Whitney U test.
  2. † 95% Confidence Interval values calculated using univariable ANOVA
  3. Definition of abbreviations: CI = cardiac index; PAH = pulmonary arterial hypertension; PCWP = pulmonary capillary wedge pressure; PAP = pulmonary artery pressure; PVR = pulmonary vascular resistance; RAP = right atrial pressure; SvO2 = mixed venous oxygen saturation.