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Table 1 Clinical characteristics of patients at the time of diagnosis of PAH.

From: Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension

BMPR2 mutation

Noncarriers

(n = 41)

Carriers

(n = 106)

P value*

Age at Diagnosis, yrs

42.0 (37.4-46.6)

36.1 (33.3-38.8)

0.04

Gender, female/male

3.1/1

2.2/1

0.43

RAP, mm Hg

12.4 (9.8-15.0)

11.1 (8.9-13.3)

0.29

Mean PAP, mm Hg

58.3 (55.0-61.5)

58.6 (55.3-61.8)

0.97

PCWP, mm Hg

10.1 (8.6-11.6)

10.6 (9.1-12.1)

0.77

CI, L/min/m2

1.8 (1.4-2.2)

1.9 (1.7-2.0)

0.92

PVR, mm Hg/L/min

14.0 (12.4-15.5)

18.1 (14.1-22.0)

0.08

SvO2, %

56.4 (52.6-60.3)

58.4 (54.5-62.3)

0.64

  1. * All P values calculated using Mann-Whitney U test.
  2. † 95% Confidence Interval values calculated using univariable ANOVA
  3. Definition of abbreviations: CI = cardiac index; PAH = pulmonary arterial hypertension; PCWP = pulmonary capillary wedge pressure; PAP = pulmonary artery pressure; PVR = pulmonary vascular resistance; RAP = right atrial pressure; SvO2 = mixed venous oxygen saturation.
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Respiratory Research

ISSN: 1465-993X

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