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Figure 8 | Respiratory Research

Figure 8

From: Gene promoter methylation assayed in exhaled breath, with differences in smokers and lung cancer patients

Figure 8

Positional correlation substructure of EBC methylation in the three promoters. The non-independence of the positions (clustering of CpG sites that are methylated appears to be non-random, for both cases and controls) suggested a different statistical analytic technique. The DAPK controls lower left, leftmost panel) shows mild grouping sufficient to define two regions (about -215 --- -113 and -84 --- +26 near the transcription initiation site). For all cases (upper right of diagonal) and RASSF1A and PAX5β controls (lower left) there is no apparent no clear grouping by region. The gradient goes from blue (no correlation, r = 0) to green to yellow to red (complete correlation, r = 1.0)

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