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Figure 1 | Respiratory Research

Figure 1

From: Gene promoter methylation assayed in exhaled breath, with differences in smokers and lung cancer patients

Figure 1

Tag-adapted sequencing chromatograms from exhaled breath condensate. For a portion (~250 bp) of the DAPK promoter region just 5' to the transcription initiation site (TIS), displayed for two representative subjects A and B. Top two tracings: Subject A (all CpG sites methylated, circled C's). The two top tracings are technical replicates from PCR to sequencing for this subject. Bottom tracing: Subject B (several CpG sites unmethylated, circled Ts). Detection of partial methylation at a given site is also feasible.

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