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Table 5 Differences in serum cytokine levels in acute and convalescence phases of rhinovirus and respiratory syncytial virus associated early wheezing episodes in corticosteroid naive children.

From: Systemic T-helper and T-regulatory cell type cytokine responses in rhinovirus vs. respiratory syncytial virus induced early wheezing: an observational study

Cytokine

Rhinovirus

RSV

Comparison of differences

 

n

Acute

Convalescence

Difference

P

n

Acute

Convalescence

Difference

P

P

Th1-type

           

IFN-gamma

9

32 (11, 60)

10 (1.1, 49)

-2.3 (-9.8, 8.6)

0.28

10

0.00 (0.00, 2.7)

0.00 (0.00, 0.00)

0.00 (-2.7, 0.00)

0.33

0.90

IL-2

9

9.99 (2.3, 13)

4.5 (0.83, 20)

-2.3 (-6.9, 2.6)

0.59

10

0.28 (0.00, 1.7)

0.70 (0.00, 2.8)

0.00 (-0.53, 0.28)

0.51

0.44

IL-12

9

13 (0.30, 16)

3.5 (0.00, 16)

-0.30 (-1.4, 3.5)

0.86

10

0.00 (0.00, 0.41)

0.00 (0.00, 2.2)

0.00 (-0.24, 0.00)

0.83

0.54

Th2-type

           

IL-4

9

190 (120, 360)

120 (34, 280)

-28 (-68, 9.5)

0.16

10

16 (0.00, 65)

43 (6.5, 150)

12 (0.00, 55)

0.34

0.037

IL-5

9

14 (7.4, 28)

3.5 (2.0, 14)

-12 (-14, -1.3)

0.16

10

0.41 (0.08, 1.0)

0.60 (0.20, 0.88)

0.13 (-0.15, 0.68)

0.60

0.046

IL-13

9

59 (25, 81)

52 (13, 70)

-7.4 (-12, 43)

0.93

10

0.00 (0.00, 3.8)

0.00 (0.00, 3.8)

0.00 (0.00, 0.00)

0.86

0.59

Treg-type

           

IL-10

9

75 (52, 120)

32 (11, 57)

-44 (-64, -22)

0.039

10

54 (39, 129)

9.1 (4.1, 14)

-50 (-121, -25)

0.0005

0.66

  1. CI, confidence interval; Th, T-helper cell; IFN, interferon; IL, interleukin; Treg, T-regulatory cell.
  2. Values are medians (interquartile range). Data were analysed by Mann Whitney U test.
  3. The unit for all cytokine levels is pg/mL.