| | | |
CpG-ODN
|
|---|
| |
PBS
|
Control ODN
|
6
|
24
|
48
|
168 (h)
|
|---|
|
IL-1β
|
4.9 ± 2.1
|
3.4 ± 0.6
|
45.4 ± 3.0*†
|
56.7 ± 6.2*†
|
62.1 ± 8.0*†
|
12.0 ± 4.0
|
|
IL-10
|
3.0 ± 0.6
|
2.6 ± 0.4
|
5.1 ± 0.3
|
51.8 ± 12.2†
|
108.4 ± 23.1*†
|
2.6 ± 0.8
|
|
IFN-γ
|
2.8 ± 0.5
|
1.3 ± 0.3
|
2.0 ± 0.3
|
110.7 ± 38.1*†
|
39.9 ± 12.6
|
1.7 ± 0.3
|
|
TNF-α
|
41.2 ± 5.6
|
37.0 ± 1.9
|
75.1 ± 12.7
|
466.1 ± 184.1*†
|
153.8 ± 50.6
|
31.3 ± 2.5
|
|
IL-6
|
7.5 ± 1.7
|
3.5 ± 0.9
|
36.9 ± 8.8
|
150.0 ± 55.4*†
|
181.3 ± 69.0*†
|
3.2 ± 0.9
|
|
IL-12p40
|
15.3 ± 4.5
|
11.8 ± 1.6
|
396.9 ± 56.9*†
|
410.9 ± 57.8*†
|
453.1 ± 79.6*†
|
111.5 ± 45.8
|
|
KC
|
1.4 ± 0.3
|
2.0 ± 0.2
|
180.8 ± 38.5*†
|
75.0 ± 25.9
|
63.6 ± 16.4
|
2.4 ± 0.3
|
|
MCP-1
|
1.4 ± 0.4
|
1.6 ± 0.4
|
55.4 ± 20.7
|
965.9 ± 206.6*†
|
1295.7 ± 204.5*†
|
3.6 ± 2.5
|
|
MIP-1α
|
11.2 ± 1.4
|
3.6 ± 1.8
|
125.5 ± 50.7
|
321.6 ± 92.2*†
|
72.3 ± 15.6
|
4.1 ± 1.8
|
|
MIP-1β
|
1.6 ± 0.5
|
1.7 ± 0.3
|
17.6 ± 6.2
|
223.9 ± 16.0*†
|
158.9 ± 37.9*†
|
1.3 ± 0.3
|
- All values (pg/mL) are expressed as the means ± SE (n = 5-6 in each group). *p < 0.05 was considered to be significantly different from the corresponding value of the PBS group. †p < 0.05 was considered to be significantly different from the corresponding value of the control ODN group.
