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Table 1 Cytokine levels in bronchoalveolar lavage fluid

From: Intratracheal synthetic CpG oligodeoxynucleotide causes acute lung injury with systemic inflammatory response

   

CpG-ODN

 

PBS

Control ODN

6

24

48

168 (h)

IL-1β

4.9 ± 2.1

3.4 ± 0.6

45.4 ± 3.0*†

56.7 ± 6.2*†

62.1 ± 8.0*†

12.0 ± 4.0

IL-10

3.0 ± 0.6

2.6 ± 0.4

5.1 ± 0.3

51.8 ± 12.2†

108.4 ± 23.1*†

2.6 ± 0.8

IFN-γ

2.8 ± 0.5

1.3 ± 0.3

2.0 ± 0.3

110.7 ± 38.1*†

39.9 ± 12.6

1.7 ± 0.3

TNF-α

41.2 ± 5.6

37.0 ± 1.9

75.1 ± 12.7

466.1 ± 184.1*†

153.8 ± 50.6

31.3 ± 2.5

IL-6

7.5 ± 1.7

3.5 ± 0.9

36.9 ± 8.8

150.0 ± 55.4*†

181.3 ± 69.0*†

3.2 ± 0.9

IL-12p40

15.3 ± 4.5

11.8 ± 1.6

396.9 ± 56.9*†

410.9 ± 57.8*†

453.1 ± 79.6*†

111.5 ± 45.8

KC

1.4 ± 0.3

2.0 ± 0.2

180.8 ± 38.5*†

75.0 ± 25.9

63.6 ± 16.4

2.4 ± 0.3

MCP-1

1.4 ± 0.4

1.6 ± 0.4

55.4 ± 20.7

965.9 ± 206.6*†

1295.7 ± 204.5*†

3.6 ± 2.5

MIP-1α

11.2 ± 1.4

3.6 ± 1.8

125.5 ± 50.7

321.6 ± 92.2*†

72.3 ± 15.6

4.1 ± 1.8

MIP-1β

1.6 ± 0.5

1.7 ± 0.3

17.6 ± 6.2

223.9 ± 16.0*†

158.9 ± 37.9*†

1.3 ± 0.3

  1. All values (pg/mL) are expressed as the means ± SE (n = 5-6 in each group). *p < 0.05 was considered to be significantly different from the corresponding value of the PBS group. †p < 0.05 was considered to be significantly different from the corresponding value of the control ODN group.