CpG-ODN | ||||||
---|---|---|---|---|---|---|
PBS | Control ODN | 6 | 24 | 48 | 168 (h) | |
IL-1β | 4.9 ± 2.1 | 3.4 ± 0.6 | 45.4 ± 3.0*† | 56.7 ± 6.2*† | 62.1 ± 8.0*† | 12.0 ± 4.0 |
IL-10 | 3.0 ± 0.6 | 2.6 ± 0.4 | 5.1 ± 0.3 | 51.8 ± 12.2† | 108.4 ± 23.1*† | 2.6 ± 0.8 |
IFN-γ | 2.8 ± 0.5 | 1.3 ± 0.3 | 2.0 ± 0.3 | 110.7 ± 38.1*† | 39.9 ± 12.6 | 1.7 ± 0.3 |
TNF-α | 41.2 ± 5.6 | 37.0 ± 1.9 | 75.1 ± 12.7 | 466.1 ± 184.1*† | 153.8 ± 50.6 | 31.3 ± 2.5 |
IL-6 | 7.5 ± 1.7 | 3.5 ± 0.9 | 36.9 ± 8.8 | 150.0 ± 55.4*† | 181.3 ± 69.0*† | 3.2 ± 0.9 |
IL-12p40 | 15.3 ± 4.5 | 11.8 ± 1.6 | 396.9 ± 56.9*† | 410.9 ± 57.8*† | 453.1 ± 79.6*† | 111.5 ± 45.8 |
KC | 1.4 ± 0.3 | 2.0 ± 0.2 | 180.8 ± 38.5*† | 75.0 ± 25.9 | 63.6 ± 16.4 | 2.4 ± 0.3 |
MCP-1 | 1.4 ± 0.4 | 1.6 ± 0.4 | 55.4 ± 20.7 | 965.9 ± 206.6*† | 1295.7 ± 204.5*† | 3.6 ± 2.5 |
MIP-1α | 11.2 ± 1.4 | 3.6 ± 1.8 | 125.5 ± 50.7 | 321.6 ± 92.2*† | 72.3 ± 15.6 | 4.1 ± 1.8 |
MIP-1β | 1.6 ± 0.5 | 1.7 ± 0.3 | 17.6 ± 6.2 | 223.9 ± 16.0*† | 158.9 ± 37.9*† | 1.3 ± 0.3 |