Figure 6

Lgl1 ^+/- mice display disorganization of elastin fibers at E18.5 and PN1. Lung sections of Lgl1 ^+/+ and Lgl1 ^+/- mice were treated with Weigert's elastin stain to visualize elastin fibres. Representative images are shown. In wild type mice, elastin fibres run longitudinally along the alveolar walls of lungs and protrude into the airspaces at the sites of secondary septal crests (see arrows). By contrast, at E18.5 and PN1 lungs of Lgl1 ^+/- mice show disorganization and fragmentation of elastin fibres (See also insets). Effects on elastin structure were less pronounced from PN7-PN14 and resolved at maturity. Magnification: 400×, insets: 1000×.