Figure 2
From: Inflammatory cytokines, goblet cell hyperplasia and altered lung mechanics in Lgl1 +/- mice
Lgl1 mRNA is reduced in the lungs of Lgl1 +/- mice. Lgl1 mRNA isolated from total lungs (A and C) or whole embryos (B) of Lgl1 +/+ and Lgl1 +/- mice was quantified by quantitative real-time RT PCR. A. and B. No significant differences in lung Lgl1 mRNA was observed from E9.5 until PN14 (p > 0.05). C. At PN28, there was significantly less Lgl1 mRNA in the lungs of Lgl1 +/- mice compared to their wild type littermates (p ≤ 0.05). D. Mature Lgl1 +/- mice display significantly reduced levels of Lgl1 mRNA in the heart when compared to their wild type littermates (p ≤ 0.05). (A. N ≥ 3 pooled litters, B. N ≥ 4, C. N ≥ 5, D. N ≥ 4)