Effects of intratracheal administration of nuclear factor-kappaB decoy oligodeoxynucleotides on long-term cigarette smoke-induced lung inflammation and pathology in mice

Table 6 Mean Group Score ± STD for Each Pathological Variable on 92 days of persistent smoke exposure.

Group	Goblet-Cell Metaplasia	Inflammatory-Cell Infiltration	Fibrosis	Muscle
NS	9.17 ± 5.05	5.50 ± 1.48	6.42 ± 2.15	5.58 ± 1.88
Decoy	3.70 ± 2.54*	6.79 ± 4.00	9.71 ± 4.27#	5.08 ± 2.42
Scr	5.30 ± 2.19	4.5 ± 1.58	4.68 ± 2.26	4.94 ± 2.59

Data were analyzed by Nonparametric Mann-Whitney U-test and expressed as mean ± STD. NS: normal saline-treated smoke-exposed mice; Decoy: decoy NF-κB ODNs-treated smoke-exposed mice; Scr: scrambled ODNs-treated smoke-exposed mice. *P < 0.05 for Decoy mice compared with NS mice, # P < 0.05 for Decoy mice compared with Scr mice. n = 5–7/per group

ISSN: 1465-993X