Lung inflammation at 92 days smoke-exposure after treatment with normal saline (NS), NF-κB decoy ODNs (Decoy) or scrambled ODNs (Scr). NF-κB decoy ODNs inhibited MIP-1α and MCP-1 but not IL-6. The level of TNF-α in BALF was increased in Decoy group, compared with the level of that in NS and Scr group. Cytokine levels were determined by ELISA and were presented as mean ± STD (n = 7–8/group). Symbols delineate statistical significance compared to NS mice (*, P < 0.05) and Scr mice (#, P < 0.05). NS: normal saline-treated smoke-induced mice; Decoy: NF-κB decoy ODNs-treated smoke-induced mice; Scr: scrambled ODNs-treated smoke-induced mice.