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Table 5 Sensitivity ratios for the different lung regions (analysis of covariance model)a

From: Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin deficiency

  PD15 (g/L)
Outcome measure LS mean change from baseline Standard error Sensitivity indexb F-testc F-testd
Whole lung -4.12 0.539 7.64 - -
Basal region -3.84 0.604 6.36 NS -
Middle region -3.82 0.673 5.68 NS 0.642
Apical region -3.80 1.001 3.80 < 0.05 < 0.05
  1. PD15, 15th percentile lung density; LS mean, least squares mean; NS, not significant.aResults based on estimates for placebo group only. bRatio of absolute value of mean change divided by standard error. cRatio of outcome measure as compared to PD15 (whole lung). dRatio of outcome measure as compared to PD15 (basal region).