|
Model with lung volume adjustment
|
---|
Outcome measure
|
LS mean change from baseline
|
Standard error
|
Sensitivity indexb
|
F-testc
|
---|
PD15 (g/L)
|
-4.12
|
0.539
|
7.64
|
-
|
MLD (g/L)
|
-3.31
|
0.801
|
4.14
|
< 0.05
|
VI-910 (%)
|
2.25
|
0.517
|
4.36
|
< 0.05
|
VI-950 (%)
|
2.36
|
0.420
|
5.61
|
NS
|
|
Model without lung volume adjustment
|
Outcome measure
|
LS mean change from baseline
|
Standard error
|
Sensitivity indexb
|
Reduction in sensitivity indexd
|
PD15 (g/L)
|
-4.24
|
0.771
|
5.50
|
2.14
|
MLD (g/L)
|
-3.49
|
1.221
|
2.86
|
1.28
|
VI-910 (%)
|
2.34
|
0.687
|
3.41
|
0.95
|
VI-950 (%)
|
2.41
|
0.514
|
4.69
|
0.92
|
- LS mean, least squares mean; PD15, 15th percentile lung density; MLD, mean lung density;
- VI-910, voxel index at a threshold of -910 (measured in %); VI-950, voxel index at a threshold of -950 (measured in %); NS, not significant. aResults based on estimates from endpoint analysis for placebo group only. bRatio of absolute value of mean change divided by standard error. cRatio of outcome measure as compared to PD15. dSensitivity index from model with lung volume adjustment minus sensitivity index from model without lung volume adjustment.