Table 6 Additive effects of genetic variations in NFE2L2 and KEAP1 on the longitudinal course of FEV1
From: Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population
Gene | Variation | Doetinchem cohort | Vlagtwedde-Vlaardingen cohort | Pooled cohorts | ||||
|---|---|---|---|---|---|---|---|---|
| Â | Â | B [ml/yr] | 95% CI | p | B [ml/yr] | 95% CI | p | p |
NFE2L2 | rs6726395 | 0.2 | -2.5 – 2.9 | 0.88 | 0.1 | -1.5 – 1.7 | 0.90 | 0.873 |
|  | rs4243387 | -1.2 | -5.6 – 3.2 | 0.60 | -1.9 | -4.8 – 1.1 | 0.21 | 0.106 |
|  | rs1806649 | 1.5 | -1.6 – 4.5 | 0.35 | 1.0 | -1.0 – 3.0 | 0.31 | 0.151 |
|  | rs13001694 | 0.0 | -2.7 – 2.7 | 1.00 | 0.7 | -1.0 – 2.4 | 0.40 | 0.337 |
|  | rs2364723 | -0.3 | -3.2 – 2.6 | 0.84 | -0.6 | -2.3 – 1.1 | 0.50 | 0.368 |
|  | Haplotype C | -0.3 | -3.8 – 3.1 | 0.85 | 0.9 | -1.3 – 3.1 | 0.40 | 0.401 |
|  | Haplotype D | -2.3 | -6.6 – 2.0 | 0.29 | 0.0 | -2.6 – 2.5 | 0.98 | 0.627 |
KEAP1 | rs1048290 | -2.0 | -4.7 – 0.8 | 0.16 | 1.0 | -0.8 – 2.8 | 0.28 | 0.907 |
|  | rs11085735 | 3.6 | -2.1 – 9.4 | 0.22 | -0.7 | -4.7 – 3.3 | 0.72 | 0.774 |
|  | rs1048287 | -1.8 | -5.9 – 2.4 | 0.41 | -0.4 | -3.1 – 2.4 | 0.80 | 0.614 |
|  | Haplotype A | -1.3 | -4.0 – 1.4 | 0.35 | 0.8 | -1.0 – 2.5 | 0.38 | 0.817 |
|  | Haplotype B | -1.6 | -4.6 – 1.4 | 0.30 | 1.5 | -0.5 – 3.4 | 0.14 | 0.573 |