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Table 6 Additive effects of genetic variations in NFE2L2 and KEAP1 on the longitudinal course of FEV1

From: Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population

Gene Variation Doetinchem cohort Vlagtwedde-Vlaardingen cohort Pooled cohorts
   B [ml/yr] 95% CI p B [ml/yr] 95% CI p p
NFE2L2 rs6726395 0.2 -2.5 – 2.9 0.88 0.1 -1.5 – 1.7 0.90 0.873
  rs4243387 -1.2 -5.6 – 3.2 0.60 -1.9 -4.8 – 1.1 0.21 0.106
  rs1806649 1.5 -1.6 – 4.5 0.35 1.0 -1.0 – 3.0 0.31 0.151
  rs13001694 0.0 -2.7 – 2.7 1.00 0.7 -1.0 – 2.4 0.40 0.337
  rs2364723 -0.3 -3.2 – 2.6 0.84 -0.6 -2.3 – 1.1 0.50 0.368
  Haplotype C -0.3 -3.8 – 3.1 0.85 0.9 -1.3 – 3.1 0.40 0.401
  Haplotype D -2.3 -6.6 – 2.0 0.29 0.0 -2.6 – 2.5 0.98 0.627
KEAP1 rs1048290 -2.0 -4.7 – 0.8 0.16 1.0 -0.8 – 2.8 0.28 0.907
  rs11085735 3.6 -2.1 – 9.4 0.22 -0.7 -4.7 – 3.3 0.72 0.774
  rs1048287 -1.8 -5.9 – 2.4 0.41 -0.4 -3.1 – 2.4 0.80 0.614
  Haplotype A -1.3 -4.0 – 1.4 0.35 0.8 -1.0 – 2.5 0.38 0.817
  Haplotype B -1.6 -4.6 – 1.4 0.30 1.5 -0.5 – 3.4 0.14 0.573
  1. Parameter estimate B (corresponding to the "per-allele" effect on the change in FEV1 in ml/yr), its 95% Confidence Interval and p value are estimated for genetic variations in NFE2L2 and KEAP1 using Linear Mixed Effect model analysis on FEV1 level adjusted for genotypes (coded: 0 = homozygotes wild type, 1 = heterozygotes, 2 = homozygotes mutant), age at entry, sex, packyears smoked, FEV1 level at baseline (and their interaction with time) and correlation of lung function measurements within subjects (random factor assigned to the intercept and time) and cohort binary variable for the pooled cohorts analysis.
  2. NFE2L2 = Nuclear Factor (Erythroid-derived 2)-Like 2
  3. KEAP1 = Kelch-like ECH-associated protein-1
  4. FEV1 = Forced Expiratory Volume in 1 second
  5. CI = Confidence Interval