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Table 5 Additive effects of NFE2L2 and KEAP1 SNPs on the level of FEV1 in never- and ever-smokers

From: Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population

   Doetinchem cohort (n = 1,152)
second survey
Vlagtwedde-Vlaardingen cohort (n = 1,390)
last survey
Gene Variation Never smokers Ever smokers Never smokers Ever smokers
   B [ml] SE p B [ml] SE p B [ml] SE p B [ml] SE p
NFE2L2 rs6726395 -33.1 34.1 0.33 -3.4 24.2 0.89 9.7 28.3 0.73 6.4 22.7 0.78
  rs4243387 15.5 55.5 0.78 -1.2 41.1 0.98 3.9 56.0 0.94 12.8 38.6 0.74
  rs1806649 -97.1 37.7 0.01 -19.0 28.4 0.50 40.6 31.5 0.20 -13.1 26.6 0.62
  rs13001694 -54.5 34.7 0.12 -16.0 24.5 0.52 13.5 28.2 0.63 5.6 23.3 0.81
  rs2364723 21.5 37.3 0.56 -36.6 26.8 0.17 -3.2 28.4 0.91 -36.2 24.0 0.13
  Haplotype C 3.5 44.6 0.94 54.2 31.3 0.08 -22.9 35.2 0.52 47.5 30.5 0.12
  Haplotype D 86.7 59.1 0.14 19.5 37.0 0.60 -40.3 42.5 0.34 38.7 37.1 0.30
KEAP1 rs1048290 -0.8 35.3 0.98 17.0 25.5 0.51 -21.8 29.2 0.46 44.6 24.6 0.07
  rs11085735 116.2 75.8 0.13 64.6 50.4 0.20 112.2 60.8 0.07 23.5 54.5 0.67
  rs1048287 -25.0 53.8 0.64 -10.4 38.7 0.79 -56.8 44.0 0.20 5.1 38.6 0.90
  Haplotype A* 25.8 34.0 0.45 22.1 24.9 0.38 4.8 28.8 0.87 36.7 23.8 0.12
  Haplotype B 12.3 38.3 0.75 2.3 27.8 0.93 3.6 30.7 0.91 46.3 26.7 0.08
  1. P values depicted in bold indicate associations significant (p < 0.05) in the pooled cohort analysis within never- or ever-smokers.
  2. *p < 0.05 for a positive recessive effect in ever and never smokers in the pooled cohort analysis (p > 0.05 for the analysis concerning separate cohorts)
  3. None of the SNP in any model showed significantly different effect between never and ever smokers as tested with the pooled cohort linear regression analysis containing interaction term (binary variable reflecting smoking status) adjusted for height, sex, age, cohort and ever/never smoking status. Two underlined KEAP1 variations showed a significant interaction with packyears smoked in an additive model within ever-smokers in the pooled cohort analysis:
  4. rs1048290: BINT = 1.9 ml/(packyear*number of alleles) SEINT = 0.9 p = 0.03
  5. Haplotype B: BINT = 1.9 ml/(packyear*number of alleles) SEINT = 0.9 p = 0.04