Table 5 Additive effects of NFE2L2 and KEAP1 SNPs on the level of FEV1 in never- and ever-smokers
From: Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population
| Â | Â | Doetinchem cohort (n = 1,152) second survey | Vlagtwedde-Vlaardingen cohort (n = 1,390) last survey | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Variation | Never smokers | Ever smokers | Never smokers | Ever smokers | ||||||||
| Â | Â | B [ml] | SE | p | B [ml] | SE | p | B [ml] | SE | p | B [ml] | SE | p |
NFE2L2 | rs6726395 | -33.1 | 34.1 | 0.33 | -3.4 | 24.2 | 0.89 | 9.7 | 28.3 | 0.73 | 6.4 | 22.7 | 0.78 |
| Â | rs4243387 | 15.5 | 55.5 | 0.78 | -1.2 | 41.1 | 0.98 | 3.9 | 56.0 | 0.94 | 12.8 | 38.6 | 0.74 |
| Â | rs1806649 | -97.1 | 37.7 | 0.01 | -19.0 | 28.4 | 0.50 | 40.6 | 31.5 | 0.20 | -13.1 | 26.6 | 0.62 |
| Â | rs13001694 | -54.5 | 34.7 | 0.12 | -16.0 | 24.5 | 0.52 | 13.5 | 28.2 | 0.63 | 5.6 | 23.3 | 0.81 |
| Â | rs2364723 | 21.5 | 37.3 | 0.56 | -36.6 | 26.8 | 0.17 | -3.2 | 28.4 | 0.91 | -36.2 | 24.0 | 0.13 |
| Â | Haplotype C | 3.5 | 44.6 | 0.94 | 54.2 | 31.3 | 0.08 | -22.9 | 35.2 | 0.52 | 47.5 | 30.5 | 0.12 |
| Â | Haplotype D | 86.7 | 59.1 | 0.14 | 19.5 | 37.0 | 0.60 | -40.3 | 42.5 | 0.34 | 38.7 | 37.1 | 0.30 |
KEAP1 | rs1048290 | -0.8 | 35.3 | 0.98 | 17.0 | 25.5 | 0.51 | -21.8 | 29.2 | 0.46 | 44.6 | 24.6 | 0.07 |
| Â | rs11085735 | 116.2 | 75.8 | 0.13 | 64.6 | 50.4 | 0.20 | 112.2 | 60.8 | 0.07 | 23.5 | 54.5 | 0.67 |
| Â | rs1048287 | -25.0 | 53.8 | 0.64 | -10.4 | 38.7 | 0.79 | -56.8 | 44.0 | 0.20 | 5.1 | 38.6 | 0.90 |
| Â | Haplotype A* | 25.8 | 34.0 | 0.45 | 22.1 | 24.9 | 0.38 | 4.8 | 28.8 | 0.87 | 36.7 | 23.8 | 0.12 |
| Â | Haplotype B | 12.3 | 38.3 | 0.75 | 2.3 | 27.8 | 0.93 | 3.6 | 30.7 | 0.91 | 46.3 | 26.7 | 0.08 |