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Table 4 Additive effects of genetic variations in NFE2L2 and KEAP1 on the level of FEV1

From: Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population

Gene Variation Doetinchem cohort Vlagtwedde-Vlaardingen cohort Pooled cohorts
   B [ml] 95% CI p B [ml] 95% CI p p
NFE2L2 rs6726395 -13.8 -51.0 – 23.4 0.47 14.1 -17.9 – 46.1 0.39 0.827
  rs4243387 0.2 -61.9 – 62.3 0.99 20.6 -36.5 – 77.7 0.48 0.620
  rs1806649 -44.5 -87.3 – -1.7 0.04 0.2 -36.7 – 37.1 0.99 0.150
  rs13001694 -20.9 -58.7 – 16.9 0.28 13.0 -19.5 – 45.5 0.43 0.948
  rs2364723 -22.9 -63.6 – 17.8 0.27 -32.1 -65.4 – 1.2 0.06 0.026
  Haplotype C 44.8 -3.4 – 93.0 0.07 24.3 -17.8 – 66.4 0.26 0.040
  Haplotype D 47.0 -12.1 – 106.1 0.11 21.2 -29.7 – 72.1 0.41 0.064
KEAP1 rs1048290 12.4 -26.3 – 51.1 0.53 -6.5 -40.8 – 27.8 0.71 0.784
  rs11085735 69.9 -9.3 – 149.1 0.08 97.1 22.4 – 171.8 0.01 0.003
  rs1048287 -11.9 -70.8 – 47.0 0.69 -33.2 -86.3 – 19.9 0.22 0.287
  Haplotype A* 23.9 -13.8 – 61.6 0.21 7.0 -26.5 – 40.5 0.68 0.206
  Haplotype B 8.9 -33.2 – 51.0 0.68 4.6 -32.5 – 41.7 0.81 0.601
  1. Significant p values are depicted in bold
  2. * for the recessive effect: B = 76.8 ml (95% CI: 8.0–145.6), p = 0.03 (Doetinchem cohort) and B = 45.1 ml (95% CI: -15.5–105.7) p = 0.14 (Vlagtwedde-Vlaardingen cohort); p = 0.01 in the pooled cohort analysis
  3. Parameter estimate B (corresponding to the "per-allele" effect on the level of FEV1 in ml), its 95% Confidence Interval and p value are estimated for genetic variations in NFE2L2 and KEAP1 using Linear Mixed Effect model analysis on FEV1 level adjusted for genotypes (coded: 0 = homozygotes wild type, 1 = heterozygotes, 2 = homozygotes mutant) packyears smoked, sex, age, height and correlation of FEV1 measurements within subjects and cohort binary variable for the pooled cohorts analysis.
  4. NFE2L2 = Nuclear Factor (Erythroid-derived 2)-Like 2
  5. KEAP1 = Kelch-like ECH-associated protein-1
  6. FEV1 = Forced Expiratory Volume in 1 second
  7. CI = Confidence Interval