Table 3 Characteristics of NFE2L2 and KEAP1 haplotypes occurring with >5% frequency in the two cohorts studied
From: Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population
Gene | Haplotype | SNP* | Frequency [%] | |
|---|---|---|---|---|
| Â | Â | rs6726395-rs4243387-rs1806649- rs13001694-rs2364723 | Doetinchem cohort | Vlagtwedde-Vlaardingen cohort |
NFE2L2 | A | 0-0-0-0-1 | 31.0 | 32.5 |
| Â | B | 1-0-1-1-0 | 25.0 | 24.5 |
| Â | C | 0-0-0-0-0 | 18.9 | 19.1 |
| Â | D | 1-0-0-1-0 | 12.4 | 13.0 |
| Â | E | 1-1-0-0-0 | 9.3 | 7.0 |
| Â | - | Rare pooled | 3.6 | 3.9 |
| Â | Â | rs1048290-rs11085735-rs1048287 | Â | Â |
KEAP1 | A | 0-0-0 | 57.7 | 57.0 |
| Â | B | 1-0-0 | 26.1 | 28.0 |
| Â | C | 1-0-1 | 9.8 | 9.7 |
| Â | D | 0-1-0 | 5.5 | 4.9 |
| Â | - | Rare pooled | 0.9 | 0.4 |