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Table 3 Characteristics of NFE2L2 and KEAP1 haplotypes occurring with >5% frequency in the two cohorts studied

From: Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population

Gene Haplotype SNP* Frequency [%]
   rs6726395-rs4243387-rs1806649- rs13001694-rs2364723 Doetinchem cohort Vlagtwedde-Vlaardingen cohort
NFE2L2 A 0-0-0-0-1 31.0 32.5
  B 1-0-1-1-0 25.0 24.5
  C 0-0-0-0-0 18.9 19.1
  D 1-0-0-1-0 12.4 13.0
  E 1-1-0-0-0 9.3 7.0
  - Rare pooled 3.6 3.9
   rs1048290-rs11085735-rs1048287   
KEAP1 A 0-0-0 57.7 57.0
  B 1-0-0 26.1 28.0
  C 1-0-1 9.8 9.7
  D 0-1-0 5.5 4.9
  - Rare pooled 0.9 0.4
  1. *0/1 corresponds to the major/minor allele of SNPs
  2. NFE2L2 = Nuclear Factor (Erythroid-derived 2)-Like 2
  3. KEAP1 = Kelch-like ECH-associated protein-1.