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Table 3 MMP mRNA levels in the in vivo model of antigen induced airway inflammation.

From: MMP/TIMP expression profiles in distinct lung disease models: implications for possible future therapies

  MMP-2 MMP-3 MMP-14 TIMP-4
2 hrs Vehicle 72.1 ± 10.2 BRDL 18.6 ± 2.3 0.3 ± 0.0
2 hrs Ovalbumin 84.3 ± 6.9 BRDL 33.8 ± 1.7
*
0.2 ± 0.1
4 hrs Vehicle 77.1 ± 11.7 BRDL 24.1 ± 4.0 0.3 ± 0.1
4 hrs Ovalbumin 71.3 ± 2.5 0.1 ± 0.0 28.7 ± 2.3 0.2 ± 0.0
6 hrs Vehicle 58.3 ± 11.5 BRDL 21.7 ± 3.6 0.3 ± 0.0
6 hrs Ovalbumin 73.0 ± 6.9 BRDL 40.9 ± 7.5
*
0.2 ± 0.1
8 hrs Vehicle 52.7 ± 3.7 BRDL 18.5 ± 2.5 0.6 ± 0.1
8 hrs Ovalbumin 64.1 ± 5 BRDL 43.5 ± 7.4
*
0.2 ± 0.1
*
12 hrs Vehicle 82.0 ± 9.7 0.2 ± 0.0 17.0 ± 3.1 0.6 ± 0.1
12 hrs Ovalbumin 71.3 ± 3.9 BRDL 50.7 ± 5.7
*
0.2 ± 0.0
*
24 hrs Vehicle 75.9 ± 5.5 0.1 ± 0.0 22.5 ± 2.1 0.3 ± 0.1
24 hrs Ovalbumin 48.3 ± 8.5
*
0.2 ± 0.0 42.0 ± 8.8 0.2 ± 0.1
*
  1. A p-value of less than 0.05 was taken as significant and denoted with *. MMP-10 and 13 were BRDL.