MMP/TIMP expression profiles in distinct lung disease models: implications for possible future therapies

Respiratory Research

Table 3 MMP mRNA levels in the in vivo model of antigen induced airway inflammation.

	MMP-2	MMP-3	MMP-14	TIMP-4
2 hrs Vehicle	72.1 ± 10.2	BRDL	18.6 ± 2.3	0.3 ± 0.0
2 hrs Ovalbumin	84.3 ± 6.9	BRDL	33.8 ± 1.7 *	0.2 ± 0.1
4 hrs Vehicle	77.1 ± 11.7	BRDL	24.1 ± 4.0	0.3 ± 0.1
4 hrs Ovalbumin	71.3 ± 2.5	0.1 ± 0.0	28.7 ± 2.3	0.2 ± 0.0
6 hrs Vehicle	58.3 ± 11.5	BRDL	21.7 ± 3.6	0.3 ± 0.0
6 hrs Ovalbumin	73.0 ± 6.9	BRDL	40.9 ± 7.5 *	0.2 ± 0.1
8 hrs Vehicle	52.7 ± 3.7	BRDL	18.5 ± 2.5	0.6 ± 0.1
8 hrs Ovalbumin	64.1 ± 5	BRDL	43.5 ± 7.4 *	0.2 ± 0.1 *
12 hrs Vehicle	82.0 ± 9.7	0.2 ± 0.0	17.0 ± 3.1	0.6 ± 0.1
12 hrs Ovalbumin	71.3 ± 3.9	BRDL	50.7 ± 5.7 *	0.2 ± 0.0 *
24 hrs Vehicle	75.9 ± 5.5	0.1 ± 0.0	22.5 ± 2.1	0.3 ± 0.1
24 hrs Ovalbumin	48.3 ± 8.5 *	0.2 ± 0.0	42.0 ± 8.8	0.2 ± 0.1 *

A p-value of less than 0.05 was taken as significant and denoted with *. MMP-10 and 13 were BRDL.

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