Table 2 BAL inflammatory cells in the three in vivo models of lung inflammation
Antigen Model | LPS Model | Elastase Model | ||||||
|---|---|---|---|---|---|---|---|---|
| Â | Neutrophils | LMN | Â | Eosinophils | LMN | Â | Neutrophils | Eosinophils |
2 hrs Veh | 0.4 ± 0.3 | 173.8 ± 16.1 | 1 hr Veh | 0.0 0.0 | 106.3 ± 20.1 | 2 hrs Veh | 21.6 ± 5.9 | 1.1 ± 0.5 |
2 hrs OVA | 11.7 ± 3.7 | 115.7 ± 18.8 | 1 hr LPS | 6.1 ± 2.2 | 102.1 ± 10.7 | 2 hrs ELA | 72.6 ± 15.8 | 0.0 ± 0.0 |
4 hrs Veh | 2.8 ± 1.6 | 181.0 ± 16.0 | 2 hrs Veh | 0.5 ± 0.3 | 155.7 ± 66.9 | 6 hrs Veh | 80.3 ± 30.5 | 1.2 ± 0.4 |
4 hrs OVA | 144.1 ± 60.1 | 99.0 ± 8.7 | 2 hrs LPS | 31.9 ± 9.6 | 71.3 ± 8.9 | 6 hrs ELA | 267 ± 86.7 | 1.9 ± 0.9 |
6 hrs Veh | 1.5 ± 0.9 | 175.7 ± 21.3 | 4 hrs Veh | 0.2 ± 0.2 | 80.7 ± 16.6 | 24 hrs Veh | 46.8 ± 22.4 | 0.9 ± 0.4 |
6 hrs OVA | 977.1 ± 300.9 | 150.7 ± 25.9 | 4 hrs LPS | 95.1 ± 24.5 | 80.0 ± 18.5 | 24 hrs ELA | 382.1 ± 77.4 | 4.3 ± 2.5 |
8 hrs Veh | 0.2 ± 0.2 | 173.9 ± 12.3 | 6 hrs Veh | 0.0 ± 0.0 | 151.8 ± 37.8 | 48 hrs Veh | 8.6 ± 2.3 | 0.0 ± 0.0 |
8 hrs OVA | 1324.5 ± 293.2 | 178.1 ± 23.0 | 6 hrs LPS | 110.0 ± 28.3 | 112.1 ± 10.5 | 48 hrs ELA | 529.4 ± 174.5 | 4.3 ± 4.3 |
12 hrs Veh | 1.6 ± 0.6 | 176.4 ± 31.9 | 8 hrs Veh | 0.0 ± 0.0 | 141.5 ± 31.5 | 72 hrs Veh | 1.1 ± 0.6 | 0.5 ± 0.2 |
12 hrs OVA | 998.7 ± 312.2 | 195.2 ± 27.0 | 8 hrs LPS | 80.6 ± 11.2 | 139.3 ± 11.7 | 72 hrs ELA | 83.2 ± 9.1 | 0.6 ± 0.6 |
24 hrs Veh | 0.7 ± 0.4 | 171.2 ± 15.9 | 12 hrs Veh | 0.1 ± 0.1 | 100.5 ± 13.9 | 96 hrs Veh | 1.9 ± 1.4 | 0.3 ± 0.3 |
24 hrs OVA | 317.4 ± 141.3 | 390.1 ± 85.9 | 12 hrs LPS | 41.3 ± 6.5 | 213.3 ± 10.4 | 96 hrs ELA | 18.1 ± 8.4 | 1.7 ± 0.9 |
|  |  |  | 24 hrs Veh | 0.1 ± 0.1 | 98.8 ± 15.9 | 168 hrs Veh | 17.2 ± 14.1 | 0.4 ± 0.4 |
|  |  |  | 24 hrs LPS | 7.9 ± 2.0 | 75.5 ± 12.9 | 168 hrs ELA | 0.6 ± 0.4 | 0.3 ± 0.3 |