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Table 1 Lung, heart and diaphragm parameters

From: Exercise intolerance and systemic manifestations of pulmonary emphysema in a mouse model

 

elastase

controls

P value

Mean linear intercept [μm]

260.7 ± 26.8

24.7 ± 1.7

<0.001

static compliance [μl/cm H 2 O]

185.1 ± 17.1

48.5 ± 5.0

<0.001

Diaphragm muscle length [mm]

5.1 ± 0.1

6.8 ± 0.3

<0.001

Tibia length [mm]

19.6 ± 0.2

19.9 ± 0.1

0.2

Heart weight [mg]

145.4 ± 5.4

148.7 ± 6.4

0.7

Right ventricular weight [mg]

44.0 ± 3.2

34.3 ± 3.2

0.055

Heart weight/tibia length [mg/mm]

7.4 ± 0.3

7.5 ± 0.3

0.95

RV weight/tibia length [mg/mm]

2.2 ± 0.2

1.7 ± 0.2

<0.05

dp/dt max [mmHg/s]

2389 ± 102

1143 ± 159

<0.0001

RV peak systolic pressure [mmHg]

38.8 ± 1.3

21.8 ± 1.2

<0.0001

RV end-diastolic pressure [mmHg]

4.6 ± 0.5

3.1 ± 0.3

<0.05

  1. Lung parameters derived from series 1 of protocol 2; diaphragm muscle length, tibia length, heart weight and hemodynamics derived from series 2 of protocol 2