From: Exercise intolerance and systemic manifestations of pulmonary emphysema in a mouse model
elastase | controls | P value | |
---|---|---|---|
Mean linear intercept [μm] | 260.7 ± 26.8 | 24.7 ± 1.7 | <0.001 |
static compliance [μl/cm H 2 O] | 185.1 ± 17.1 | 48.5 ± 5.0 | <0.001 |
Diaphragm muscle length [mm] | 5.1 ± 0.1 | 6.8 ± 0.3 | <0.001 |
Tibia length [mm] | 19.6 ± 0.2 | 19.9 ± 0.1 | 0.2 |
Heart weight [mg] | 145.4 ± 5.4 | 148.7 ± 6.4 | 0.7 |
Right ventricular weight [mg] | 44.0 ± 3.2 | 34.3 ± 3.2 | 0.055 |
Heart weight/tibia length [mg/mm] | 7.4 ± 0.3 | 7.5 ± 0.3 | 0.95 |
RV weight/tibia length [mg/mm] | 2.2 ± 0.2 | 1.7 ± 0.2 | <0.05 |
dp/dt max [mmHg/s] | 2389 ± 102 | 1143 ± 159 | <0.0001 |
RV peak systolic pressure [mmHg] | 38.8 ± 1.3 | 21.8 ± 1.2 | <0.0001 |
RV end-diastolic pressure [mmHg] | 4.6 ± 0.5 | 3.1 ± 0.3 | <0.05 |