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Figure 4 | Respiratory Research

Figure 4

From: Modulation of lung inflammation by vessel dilator in a mouse model of allergic asthma

Figure 4

VD attenuates lung inflammation in BALB/c mice. (A) Mice were sensitized and challenged with OVA and then given nanoparticles containing pVD or control pVAX1 plasmids. Mice were sacrificed 48 hrs after the final treatment, and BAL fluids were collected for differential cell counts. Values are reported as mean ± SEM. Treatment with pVD significantly reduced eosinophil recruitment to the lungs compared to pVAX1 control (p < 0.05). Mac, macrophages; Eos, eosinophils; Neu, neutrophils; Lym, lymphocytes. (B) Lung sections from mice treated with VD nanoparticles also showed a substantial decrease in lung inflammation, goblet cell hyperplasia and infiltration of inflammatory cells compared to the non-OVA-challenged group or the group treated with pVAX1. All experiments were repeated and the results of a representative experiment are shown.

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