Figure 3
From: Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice
Development of hypoxic pulmonary hypertension and vascular remodeling in IL-6 +/+ and IL-6 -/- mice. Right ventricular systolic pressure (RVSP) (a) and weights of the right ventricle/left ventricle + septum (Fulton's index) (b) in IL-6+/+ and IL-6-/- mice exposed to normoxia or 10% O2 for 2 weeks. **P < 0.01 compared to IL-6+/+ mice under similar conditions. Percentage of muscularized vessels from wild-type IL-6+/+ and IL-6-/- mice (c). Twenty to thirty intraacinar vessels were examined in each lung from mice of each genotype after exposure to hypoxia for 2 weeks. Percentages of nonmuscular (NM), partially muscular (PM), and fully muscular (M) vessels differed significantly between IL-6+/+ and after 2 weeks of hypoxia (P < 0.05). Normalized wall thickness measured in fully muscular arteries in lungs from IL-6-/- and IL-6+/+ mice exposed to hypoxia for 2 weeks (d). *P < 0.05 compared to IL-6+/+ mice exposed to hypoxia for 2 weeks.