Figure 2
From: Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation
Pulmonary function during reperfusion in A 2A AR KO mice. Pulmonary artery pressure (A), airway resistance (B), and pulmonary compliance (C) were measured throughout 60 min reperfusion in A2AAR KO lungs after IR with or without administration of ATL313. Lung function was significantly impaired in A2AAR KO mice, and ATL313 treatment offered no protection. Open circles, WT Sham lungs undergoing perfusion only; filled circles, WT IR lungs reperfused after 60 min ischemia; filled triangles, A2AAR KO IR lungs reperfused after 60 min ischemia; open triangles, A2AAR KO IR lungs treated with ATL313 (30 nM) during reperfusion. *p < 0.01 WT Sham vs. all.