Figure 1

Temporal changes in pulmonary function during reperfusion. Pulmonary artery pressure (A), airway resistance (B), and pulmonary compliance (C) were measured throughout 60 min reperfusion in WT sham and IR lungs. Lung function is significantly impaired after IR compared to sham, and ATL313 significantly attenuated lung dysfunction. Open circles, Sham lungs undergoing perfusion only; filled circles, IR lungs reperfused after 60 min ischemia; filled triangles, IR lungs treated with ATL313 (30 nM) during reperfusion. *p < 0.01 IR vs. all.