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Table 5 Table of results of the multivariate analyses performed to determine the independent associations between the variables

From: COPD phenotype description using principal components analysis

Independent Predictor Dependent Variable
  FeNO Sputum TCC Sputum Neutrophil
TCC
Sputum Neutrophil % Sputum Eosinophil
TCC
Sputum Eosinophil
%
Sputum
IL8
FeNO N/A NS NS P < 0.0001
R = -0.6
P < 0.0001
R = 0.7
P < 0.0001
R = 0.62
NS
Sputum IL8 NS NS P = 0.002
R = 0.57
P < 0.0001
R = -0.6
NS NS N/A
Plasma
TNFα
NS NS P < 0.0001
R = 0.57
NS NS NS P = 0.01
R = 0.44
Smoking P < 0.0001
R = 0.72
(lower in smokers)
NS NS NS NS NS NS
Reversibility NS NS NS P = 0.01
R = -0.6
P = 0.02
R = 0.7
NS NS
Gender P = 0.04
R = 0.7
(lower in females)
NS NS NS NS NS NS
  1. FEV1, IC, BMI, Bronchodilator reversibility, plasma CRP, ICS usage and smoking pack years did not predict any of the variables marking airway inflammation.
  2. P and R values were determined by linear regression multivariate analysis.
  3. NS : No significant association.
  4. TNFα; tumour necrosis factor-alpha, TCC; total cell count.