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Table 5 Table of results of the multivariate analyses performed to determine the independent associations between the variables

From: COPD phenotype description using principal components analysis

Independent Predictor

Dependent Variable

 

FeNO

Sputum TCC

Sputum Neutrophil

TCC

Sputum Neutrophil %

Sputum Eosinophil

TCC

Sputum Eosinophil

%

Sputum

IL8

FeNO

N/A

NS

NS

P < 0.0001

R = -0.6

P < 0.0001

R = 0.7

P < 0.0001

R = 0.62

NS

Sputum IL8

NS

NS

P = 0.002

R = 0.57

P < 0.0001

R = -0.6

NS

NS

N/A

Plasma

TNFα

NS

NS

P < 0.0001

R = 0.57

NS

NS

NS

P = 0.01

R = 0.44

Smoking

P < 0.0001

R = 0.72

(lower in smokers)

NS

NS

NS

NS

NS

NS

Reversibility

NS

NS

NS

P = 0.01

R = -0.6

P = 0.02

R = 0.7

NS

NS

Gender

P = 0.04

R = 0.7

(lower in females)

NS

NS

NS

NS

NS

NS

  1. FEV1, IC, BMI, Bronchodilator reversibility, plasma CRP, ICS usage and smoking pack years did not predict any of the variables marking airway inflammation.
  2. P and R values were determined by linear regression multivariate analysis.
  3. NS : No significant association.
  4. TNFα; tumour necrosis factor-alpha, TCC; total cell count.