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Table 5 Sensitivity and specificity of challenge at different cut points for a positive test.

From: Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma

Exercise Positive Cut-Points – % fall from baseline 10% 15% 20%
Mannitol Sensitivity 58.6 69.4 78.6
   n = 372 Specificity 65.2 62.0 60.8
Excluding those with challenge > 35 min Sensitivity 64.1 75.3 82.7
   n = 319 Specificity 59.9 57.0 55.4
Methacholine 16 mg/ml Sensitivity 55.2 67.4 80.3
   n = 375 Specificity 68.9 66.1 65.2