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Figure 2 | Respiratory Research

Figure 2

From: Silencing CD36 gene expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the rat

Figure 2

Quantity of TGF-β1 and the percentage of active TGF-β1 in BALF. (A–a) The quantity of total and active TGF-β1 in the silica, silica+Lv-shCD36, and silica+Lv-shCD36-NC groups were significantly higher than in the saline control group at 7 days after instillation. The quantity of active TGF-β1 in the silica+Lv-shCD36 group was significantly lower than in the silica and silica+Lv-shCD36-NC groups at 7 days. (A–b) The percentage of active TGF-β1 in the silica+Lv-shCD36 group was significantly lower than in the silica and silica+Lv-shCD36-NC groups, and it was significantly higher than in the saline control group at 7 days after instillation. (B–a) The quantity of total and active TGF-β1 in the silica group, the silica+Lv-shCD36 group and the silica+Lv-shCD36-NC group were significantly higher than in the saline control group at 21 days after instillation. (B–b) The percentage of active TGF-β1 in the silica group, the silica+Lv-shCD36 group and the silica+Lv-shCD36-NC group were significantly higher than in the saline control group at 21 days after instillation. Each bar represents the mean ± SEM. **P < 0.05, as compared to the quantity of total TGF-β1 in the saline control group; *P < 0.05, as compared to the quantity of active TGF-β1 in the saline control group; Δ P < 0.05, as compared to the quantity of active TGF-β1 in the silica group; # P < 0.05, as compared to the quantity of active TGF-β1 in the silica+Lv-shCD36-NC group. The data represent the means from experiments done in six rats.

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