Figure 5
From: Adult onset lung disease following transient disruption of fetal stretch-induced differentiation
Respiratory function with age following in-utero gene transfer at 16 days gestation. Respiratory function testing at 17, 30, 90, 120 days and 18 months, (PEEP 3 shown) following in utero treatment with an adenovirus containing either EGFP, (control, solid lines), or anti-sense CFTR gene fragment, (ASCFTR, dashed lines). (A) static compliance (Cst). (B) conducting airway resistance, (Raw). (C) elastance (D) tissue damping. (E) hysteresivity, (eta). All data were obtained in triplicate. Eight animals are included in each data point. Error bars are ± standard error of mean. Results at PEEP of 0 and 6 were similar, (data not shown). *p < 0.05.