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Figure 6 | Respiratory Research

Figure 6

From: Simvastatin ameliorates established pulmonary hypertension through a heme oxygenase-1 dependent pathway in rats

Figure 6

Changes in HO activity in MCT-PH (A) and CH-PH (B) rat lungs. Simvastatin treatment (MS and HS groups) significantly increased HO activity compared with non-simvastatin treatment in PH rats (M and H groups). Co-administration of simvastatin and SnPP (MSP and HSP groups) led to significantly less HO activity than in simvastatin-treated rats (MS and HS groups). The bilirubin concentration in each group was normalized to that of normal controls (Group N, value = 1.0). Horizontal bars indicate groups that differed significantly from each other, * p < 0.05.

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