Figure 2

Effects of simvastatin and SnPP on pulmonary arterial pressure in MCT-PH (A) and CH-PH (B) rats. Rats that received simvastatin (MS and HS groups) had significantly decreased pulmonary arterial pressure compared with non-simvastatin treated PH rats (M and H groups). Co-treatment with simvastatin and SnPP (MSP and HSP groups) failed to relieve the high pulmonary arterial pressure. Rats that received SnPP alone (MP and HP groups) maintained high pulmonary arterial pressure. Horizontal bars indicate groups that differed significantly from each other, * p < 0.05. (N = normal control, M = monocrotaline treatment, MS = monocrotaline + simvastatin treatment, MSP = monocrotaline + simvastatin + SnPP treatment, MP = monocrotaline + SnPP treatment, H = chronic hypoxia, HS = chronic hypoxia + simvastatin treatment, HSP = chronic hypoxia + simvastatin + SnPP treatment, HP = chronic hypoxia + SnPP treatment).