Figure 1

Schematic outline of the experimental protocol. Monocrotaline-induced pulmonary hypertension (MCT-PH) was established by subcutaneous administration on day 1 (60 mg/kgw), and chronic hypoxia-induced pulmonary hypertension (CH-PH) was established by treatment in a hypobaric chamber (380 Torr, intermittent exposure) for 24 days. Simvastatin was given by intraperitoneal injection (10 mg/kgw/day) on day 21~23, and SnPP (20 μmol/kgw/day) was injected alone or with simvastatin simultaneously on days 21~23. All animals underwent experimental surgery on day 24.