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Table 3 Relative expression of genes encoding for proteins involved in lipid synthesis and uptake

From: Particles induce apical plasma membrane enlargement in epithelial lung cell line depending on particle surface area dose

Particle size: 1 μm

Exposure time

2 h

4 h

8 h

12 h

24 h

HMG CoA Synthase

1.23 (0.34)

1.33 (0.23)

0.80 (0.38)

1.38 (0.42)

1.26 (0.16)

HMG CoA Reductase

1.37 (0.18)

1.12 (0.16)

0.95 (0.16)

1.41 (0.12)

1.33 (0.29)

LDL Receptor

1.33 (0.24)

1.20 (0.21)

1.06 (0.48)

1.24 (0.01)

1.48 (0.31)

Fatty Acid Synthase

1.05 (0.03)

0.91 (0.09)

0.92 (0.34)

0.93 (0.24)

1.26 (0.46)

Particle size: 0.05 μm

Exposure time

2 h

4 h

8 h

12 h

24 h

HMG CoA Synthase

1.44 (0.38)

1.11 (0.15)

1.02 (0.12)

1.03 (0.24)

1.00 (0.18)

HMG CoA Reductase

1.08 (0.15)

0.99 (0.17)

0.99 (0.05)

1.03 (0.06)

1.04 (0.29)

LDL Receptor

1.28 (0.20)

1.05 (0.05)

1.06 (0.17)

0.83 (0.11)

1.40 (0.42)

Fatty Acid Synthase

1.15 (0.17)

0.94 (0.04)

1.09 (0.26)

0.97 (0.17)

1.19 (0.40)

  1. Note: Induction of mRNA of each gene relative to the negative control after different exposure times for 6 × 108 1 μm particles and 4.5 × 1011 0.05 μm particles. The results show the mean of three experiments (standard deviation).